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Glossary entry

English term or phrase:

targeted cell death

Spanish translation:

Muerte celular selectiva

Added to glossary by Samuel Sebastian Holden Bramah
Jan 21, 2015 10:07
9 yrs ago
7 viewers *
English term

targeted cell death

English to Spanish Medical Medical (general)
The treatment causes targeted cell death, known as apoptosis.

El doctor explica al paciente qué es lo que hará el procedimiento. Tengo una idea de "targeted", pero quisiera saber vuestras opiniones.
Proposed translations (Spanish)
4 +3 Muerte celular selectiva
4 +1 muerte celular programada
5 muerte de las células diana
4 -1 el tratamiento mata solo las células patológicas
Change log

Jan 28, 2015 12:03: Samuel Sebastian Holden Bramah Created KOG entry

Discussion

Charles Davis Jan 22, 2015:
AGCAL's reference is perfectly sound in itself but it's about natural apoptosis. This text is presumably about induced apoptosis.
Charles Davis Jan 22, 2015:
It's true that the treatment may well work by inducing the cell to kill itself by sending it the chemical messenger(s) it is programmed to receive. But that still cannot properly be called programmed cell death, because the chemical process itself was not programmed; it was induced. It is not an accident that the source text has used the term "targeted" and not the term "programmed".
lugoben Jan 22, 2015:
Charles The human body is a very complex machine. Due to the possibility of anything going wrong inside it, cells are told to self destroy if it passes its permitted living time or if it is wrongly formed. Steps are taken to help the cell achieve its final stage. So there is a kind of control to make sure things don't get out of hands. Every cells is targeted to arrive at this condition should it be necessary. Thanks for the discussion.
Carmen Herrera Jan 22, 2015:
I see your point Charles Davis, but according to the reference kindly given by AGCAL, apoptosis eliminates unwanted cells, hence targeted:
El segundo tipo de muerte celular
es conocido como apoptosis o muerte
celular programada. En este proceso
las células se autodestruyen sin
desencadenar reacciones de inflamación
ni dejar cicatrices en los tejidos.
La apoptosis es por tanto considerada
como una muerte natural fisiológica,
resultando en un mecanismo
de eliminación de células no deseadas,
dañadas o desconocidas y que
desempeña un papel protector frente
a posibles enfermedades.
Charles Davis Jan 22, 2015:
@lugoben Absolutely correct. But "targeted" doesn't mean that; it means that particular cells are targeted by the treatment.
lugoben Jan 22, 2015:
Charles A cell is given a certain time to stay alive. If it comes to its end the cell sends signals of distress. This sets up a combination of enzymes to be present helping the cell reach its end. I the cell finds a way of extending its time it will be given an opportunity to redeem itself. This is called apoptosis. The cell is programmed to destroy itself because the number of cells that are in apoptosis process normally is in the order of billions. A faulty cell death may produce disease and possibly cancer.
Charles Davis Jan 21, 2015:
A treatment can't cause programmed cell death. The cause of PCD is genetic.

Proposed translations

+3
5 mins
Selected

Muerte celular selectiva

Una forma de decirlo...

--------------------------------------------------
Note added at 25 mins (2015-01-21 10:32:48 GMT)
--------------------------------------------------

De nada ;)
Note from asker:
gracias!
Peer comment(s):
agree Charles Davis : I don't think muerte celular programada is correct here, and if they'd meant that they'd have put programmed cell death. It's not programmed here; it's induced.
2 hrs
I agree, since here I assume it is some form of cancer treatment and the idea is to target and destroy certain cells, and not have them die naturally
agree Alejandra Contreras : Maybe "específica" could work as well...
6 hrs
agree Barbara Thomas : La validez de esta traducción depende del contexto, pero el sentido es correcto.
3 days 9 hrs
Something went wrong...
4 KudoZ points awarded for this answer.
+1
41 mins

muerte celular programada

Peer comment(s):
agree Ángeles García-Calderón : http://scholar.google.es/scholar?q=muerte celular programada...
1 hr
Gracias AGCAL
disagree Samuel Sebastian Holden Bramah : I think in this context it means something else... since programmed cell death is when they die "naturally" or at least when they are supposed to through "biological programming", the concept here is a forced death.
2 hrs
agree cristina orriols
2 hrs
Gracias Cristina
agree lugoben : I think you are on the right track. AGCAL reference is clear
1 day 2 hrs
Thank you Lugoben
disagree Barbara Thomas : Muerte celular programada es un sinónimo de apoptosis.
3 days 8 hrs
Something went wrong...
-1
6 hrs

el tratamiento mata solo las células patológicas


Otra opción considerando que es una explicación al paciente por lo que es preferible que el lenguaje sea más claro y directo. De hecho lo compara con la apoptosis, que es el proceso natural de deshacerse de las células que ya no sirven.
Peer comment(s):
disagree Barbara Thomas : Ya quisieran los laboratorios poder producir un fármaco así; generalmente seleccionan como diana un proceso más activo en las células patológicas pero también existente en otras células, por lo que su acción no es exclusiva.
6 days
Something went wrong...
3 days 9 hrs

muerte de las células diana

No conozco el contexto, pero hay muchos ejemplos:

"Posteriormente, se desencadena un mecanismo lítico, dependiente sobre todo de la secreción dirigida por parte del linfocito C citotóxico, de unos gránulos citoplásmicos que contienen proteínas citotóxicas que acaban induciendo la muerte de la célula “diana”."

http://www.aragoninvestiga.org/Caracterizacion-de-los-mecani...


"Por otro lado, a la apoptosis se le ha asignado un papel en el control de eventos del sistema inmune, como la selección de linfocitos T y B, la muerte citotóxica de células diana o la inducción de apoptosis por citoquinas."

http://www.rac.es/ficheros/doc/00553.pdf


"Este receptor y su ligando desempeñan un papel importante en modelos apoptóticos como son la supresión periférica de las células T maduras al final de una respuesta inmune, la muerte de células diana (células infectadas por virus), la destrucción de células cancerosas mediada por células T citotóxicas y por natural killer, así como la eliminación de las células inmunes reactivas a tumores que expresan constitutivamente el ligando de Fas."

http://www.dfarmacia.com/farma/ctl_servlet?_f=37&id=13049112
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